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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SMPD4
All Species:
20
Human Site:
S572
Identified Species:
44
UniProt:
Q9NXE4
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q9NXE4
NP_060221.2
827
93352
S572
K
H
T
A
K
S
I
S
D
Q
C
A
E
S
P
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_543560
827
93189
S572
K
Q
T
A
K
S
I
S
D
Q
C
G
E
S
T
Cat
Felis silvestris
Mouse
Mus musculus
Q6ZPR5
823
93257
S568
K
Q
T
A
K
S
I
S
D
Q
Y
V
E
S
P
Rat
Rattus norvegicus
NP_001161278
823
93261
S568
K
Q
T
A
K
S
I
S
D
Q
C
V
E
S
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001509989
509
58534
A262
S
D
H
S
A
E
N
A
A
S
Q
S
F
F
S
Chicken
Gallus gallus
XP_415236
827
94779
S573
Q
Q
T
A
K
S
I
S
D
H
S
A
E
T
T
Frog
Xenopus laevis
Q5XHG1
824
93777
S572
K
Q
T
A
K
S
I
S
N
H
S
P
D
S
S
Zebra Danio
Brachydanio rerio
Q6PFJ7
791
89972
S538
R
Q
T
A
K
R
I
S
D
H
S
T
E
M
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_650124
767
86929
R517
L
L
L
I
S
M
A
R
N
S
V
L
R
D
I
Honey Bee
Apis mellifera
XP_623882
744
86631
F497
F
L
A
L
W
E
F
F
Y
G
E
D
Y
S
S
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784153
874
98584
V607
I
T
Q
A
Q
T
T
V
K
T
M
A
G
P
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
92
N.A.
89.8
90.3
N.A.
46.1
74.9
66.2
60.5
N.A.
24.2
29.5
N.A.
31
Protein Similarity:
100
N.A.
N.A.
94.5
N.A.
93.8
93.9
N.A.
51.8
83.9
77.6
71.9
N.A.
42.2
47.4
N.A.
49.2
P-Site Identity:
100
N.A.
N.A.
80
N.A.
80
86.6
N.A.
0
60
53.3
46.6
N.A.
0
6.6
N.A.
13.3
P-Site Similarity:
100
N.A.
N.A.
80
N.A.
80
86.6
N.A.
20
73.3
66.6
53.3
N.A.
6.6
6.6
N.A.
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
73
10
0
10
10
10
0
0
28
0
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
28
0
0
0
0
% C
% Asp:
0
10
0
0
0
0
0
0
55
0
0
10
10
10
0
% D
% Glu:
0
0
0
0
0
19
0
0
0
0
10
0
55
0
0
% E
% Phe:
10
0
0
0
0
0
10
10
0
0
0
0
10
10
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
10
0
10
10
0
0
% G
% His:
0
10
10
0
0
0
0
0
0
28
0
0
0
0
0
% H
% Ile:
10
0
0
10
0
0
64
0
0
0
0
0
0
0
10
% I
% Lys:
46
0
0
0
64
0
0
0
10
0
0
0
0
0
0
% K
% Leu:
10
19
10
10
0
0
0
0
0
0
0
10
0
0
0
% L
% Met:
0
0
0
0
0
10
0
0
0
0
10
0
0
10
0
% M
% Asn:
0
0
0
0
0
0
10
0
19
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
10
0
10
28
% P
% Gln:
10
55
10
0
10
0
0
0
0
37
10
0
0
0
0
% Q
% Arg:
10
0
0
0
0
10
0
10
0
0
0
0
10
0
0
% R
% Ser:
10
0
0
10
10
55
0
64
0
19
28
10
0
55
37
% S
% Thr:
0
10
64
0
0
10
10
0
0
10
0
10
0
10
19
% T
% Val:
0
0
0
0
0
0
0
10
0
0
10
19
0
0
0
% V
% Trp:
0
0
0
0
10
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
10
0
10
0
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _